Jenkins, V.A., Shilling, V, Deutsch, G., Bloomfield, D., Morris, R., Allan, S., Bishop, H., Hodson, N., Mitra, S., Sadler, G., Shah, E., Stein, R., Whitehead, S. and Winstanley, J. (2006) A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer. British Journal of Cancer, 94 (6). pp. 828-34. ISSN 0007-0920Full text not available from this repository.
The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis found no significant interactions or main effect of group after controlling for age and intelligence. Using a calculation to examine performance at an individual level, reliable decline on multiple tasks was seen in 20% of chemotherapy patients, 26% of nonchemotherapy patients and 18% of controls at T2 (18%, 14 and 11%, respectively, at T3). Patients who had experienced a treatment-induced menopause were more likely to show reliable decline on multiple measures at T2 (OR=2.6, 95% confidence interval (CI) 0.823-8.266 P=0.086). Psychological distress, quality of life measures and self-reported cognitive failures did not impact on objective tests of cognitive function, but were significantly associated with each other. The results show that a few women experienced objective measurable change in their concentration and memory following standard adjuvant therapy, but the majority were either unaffected or even improve over time.
|Additional Information:||0007-0920 (Print) Journal Article Research Support, Non-U.S. Gov't|
|Keywords:||Adult Aged Antineoplastic Agents, Hormonal/*adverse effects/therapeutic use Breast Neoplasms/*drug therapy/*psychology/radiotherapy Case-Control Studies Chemotherapy, Adjuvant/adverse effects Cognition Disorders/*etiology Female Humans Intelligence Memory Disorders/etiology Middle Aged Neuropsychological Tests Prospective Studies Quality of Life Radiotherapy, Adjuvant/adverse effects Stress, Psychological Endocrine Treatment Cognitive Dysfunction|
|Schools and Departments:||Brighton and Sussex Medical School > Sussex Health Outcomes Research & Education in Cancer (SHORE-C)|
|Subjects:||B Philosophy. Psychology. Religion > BF Psychology > BF0309 Consciousness. Cognition Including learning, attention, comprehension, memory, imagination, genius, intelligence, thought and thinking, psycholinguistics, mental fatigue
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology Including cancer and carcinogens
R Medicine > RG Gynecology and obstetrics > RG0491 Diseases of the breast
R Medicine > RM Therapeutics. Pharmacology > RM0260 Chemotherapy
|Depositing User:||Tracy Woodcock|
|Date Deposited:||09 Nov 2011 10:20|
|Last Modified:||16 Aug 2016 10:23|
|Google Scholar:||145 Citations|