A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years

Moghadam, Azam Rastgar, Mehramiz, Mehramiz, Entezar, Malihe, Aboutalebi, Hamideh, Kohansal, Fatemeh, Dadjoo, Parisa, Fiuji, Hamid, Nasiri, Mohammadreza, Aledavood, Seyed Amir, Simab, Saeideh Ahmadi, Khorrami, Mohammad Sadegh, Moradi, Ali, Hassanian, Seyed Mahdi, Ferns, Gordon A, ShahidSales, Soodabeh and Avan, Amir (2018) A genetic polymorphism in the CYP1B1 gene in patients with squamous cell carcinoma of the esophagus: an Iranian Mashhad cohort study recruited over 10 years. The Pharmacogenomics Journal, 19 (6). pp. 539-546. ISSN 1470-269X,

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Abstract

Background: Esophageal-cancer is the seventh most common-cause of cancer-related-deaths in men. Cytochrome-P450-family-1-subfamily-B-polypeptide-1 (CYP1B1) plays a role in the metabolism of xenobiotics, and is associated with several cancers. Here we investigated the association between a genetic-variant, CYP1B1-rs1056836, with the clinical-characteristics of patients with esophagus-squamous-cell-carcinoma (ESCC).
Method: 117-patients with ESCC and 208 healthy-subjects were recruited. DNA was extracted and genotyped. Kaplan-Meier curves were utilized to assess overall and progression-free survival. The relationship between clinicopathological-data, disease-prognosis, and survival, were evaluated with the genotypes.
Results: the genotypic frequency for GG, GC, and CC were 58.6%, 29.8%, 11.5% respectively in the healthy subjects and 51.8%, 36.14% and 12% in the ESCC group. An association between the GG genotype and stage of ESCC was found.
Conclusion: Our findings suggest a relationship between the CYP1B1-rs1056836 genetic polymorphism and clinical features of ESCC, supporting further studies in larger-populations in different-ethnic groups, taking into account potentially important environmental-factors.

Item Type: Article
Keywords: cytochrome p450, esophagus squamous cell carcinoma
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Gordon Ferns
Date Deposited: 07 Mar 2018 16:03
Last Modified: 22 May 2018 15:52
URI: http://sro.sussex.ac.uk/id/eprint/74278

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