Host genes that affect progression of AIDS/HIV in India and novel gene therapeutic approaches against HIV

Sood, Vikas, Rathore, Anurag, Husain, Sajid, Khan, Sohrab, Patra, Shruti, Shankar, Vijay, Kumar, Harsh, Rani, Neha, Bano, Aalia S, Neogi, Ujjwal, Ramachandran, V G and Banerjea, Akhil C (2008) Host genes that affect progression of AIDS/HIV in India and novel gene therapeutic approaches against HIV. Indian Journal of Biochemistry and Biophysics, 45 (3). pp. 141-148. ISSN 0301-1208

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Abstract

A multitude of host and viral factors play critical role in susceptibility to HIV-1 infection and its subsequent progression to AIDS. Various host factors involved in HIV-1 infection include the chemokine receptors CCR5, CX3CR1, their ligands, RANTES, SDF-1 and cytokines like IL-10, IL-4, among others. The CCR5Δ32 allele is the most important genetic factor known to confer resistance to HIV-1 infection. However, other mutations in CCR5, CX3CR1 and SDF-1 have also been identified in Indian population. Polymorphisms in DC-SIGN, MHC class-I and II molecules are also known to affect HIV-1 progression. These polymorphisms can be utilized as genetic markers for evaluating disease progression and developing effective therapeutics. The review also describes the development of anti-viral therapy, involving the use of catalytic nucleic acids like DNA-enzymes and ribozymes and the expression of ribozymes and si-RNA using lentiviral vectors for stem cell based anti-HIV therapy.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R852 Research. Experimentation
Depositing User: Sandy Gray
Date Deposited: 02 Mar 2018 10:40
Last Modified: 02 Mar 2018 10:40
URI: http://sro.sussex.ac.uk/id/eprint/74165

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