Neutrophil kinetics in health and disease

Summers, Charlotte, Rankin, Sara M., Condliffe, Alison M., Singh, Nanak, Peters, A. Michael and Chilvers, Edwin R. (2010) Neutrophil kinetics in health and disease. Trends in Immunology, 31 (8). pp. 318-324. ISSN 1471-4906

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Abstract

Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived with a circulating half life of 6-8 h and hence are produced at a rate of 5 x 10(10)-10 x 10(10) cells/day. Tight regulation of these cells is vital because they have significant histotoxic capacity and are widely implicated in tissue injury. This review outlines our current understanding of how neutrophils are released from the bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis, the relative size and role of the freely circulating and marginated (i.e. slowly transiting) pools within the vascular compartment, and the events that result in the uptake and removal of circulating neutrophils. We also review current understanding of how systemic stress and inflammation affect this finely balanced system.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: Q Science > QR Microbiology > QR0180 Immunology
Depositing User: Grecia GarciaGarcia
Date Deposited: 12 Sep 2011 10:42
Last Modified: 01 Sep 2017 10:14
URI: http://sro.sussex.ac.uk/id/eprint/7387
Google Scholar:27 Citations
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