How I manage haematology patients with septic shock

Cohen, Jonathan and Drage, Stephen (2011) How I manage haematology patients with septic shock. British Journal of Haematology, 152 (4). pp. 380-391. ISSN 0007-1048

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Abstract

Patients with a variety of haematological conditions are at risk of infection and its most serious complication: septic shock. Mortality for septic shock remains high and especially so in patients with haematological malignancy and following bone marrow transplantation. However, advances in the treatment of severe sepsis have improved mortality rates even though evidence for the management of severe sepsis in haematology patients is limited. Wherever possible this review will concentrate on evidence directly applicable to haematology patients but inevitably will have to extrapolate evidence from other patient groups. The Surviving Sepsis Guidelines 2008 provide information on best practice in the management of patients with severe sepsis and septic shock and are broadly applicable though not specific to haematology patients. This review summarizes a practical approach to the management of severe sepsis in haematology patients and highlights areas of research which may bring new treatments in the future. The review is limited to the management and initial resuscitation of septic shock in adult haematology patients and will not address the detailed intensive care management of these patients or the management of severe sepsis in children.

Item Type: Article
Keywords: sepsis, septic shock, haematological malignancy, leukaemia, bone marrow transplantation
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Depositing User: Grecia GarciaGarcia
Date Deposited: 08 Sep 2011 09:18
Last Modified: 11 Jun 2012 14:16
URI: http://sro.sussex.ac.uk/id/eprint/7375
Google Scholar:4 Citations
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