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Antiviral therapies against Ebola and other emerging viral diseases using existing medicines that block virus entry

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posted on 2023-06-09, 11:56 authored by Jason Long, Edward WrightEdward Wright, Eleonora Molesti, Nigel Temperton, Wendy Barclay
Emerging viral diseases pose a threat to the global population as intervention strategies are mainly limited to basic containment due to the lack of efficacious and approved vaccines and antiviral drugs. The former was the only available intervention when the current unprecedented Ebolavirus (EBOV) outbreak in West Africa began. Prior to this, the development of EBOV vaccines and anti-viral therapies required time and resources that were not available. Therefore, focus has turned to re-purposing of existing, licenced medicines that may limit the morbidity and mortality rates of EBOV and could be used immediately. Here we test three such medicines and measure their ability to inhibit pseudotype viruses (PVs) of two EBOV species, Marburg virus (MARV) and avian influenza H5 (FLU-H5). We confirm the ability of chloroquine (CQ) to inhibit viral entry in a pH specific manner. The commonly used proton pump inhibitors, Omeprazole and Esomeprazole were also able to inhibit entry of all PVs tested but at higher drug concentrations than may be achieved in vivo. We propose CQ as a priority candidate to consider for treatment of EBOV.

History

Publication status

  • Published

File Version

  • Published version

Journal

F1000Research

ISSN

2046-1402

Publisher

F1000Research

Issue

30

Volume

4

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-02-07

First Open Access (FOA) Date

2018-02-07

First Compliant Deposit (FCD) Date

2018-02-06

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