Theories of signs define a novel approach to the analysis of clinical biomarkers of inflammation and oxidative stress

Ghezzi, Pietro, Davies, Kevin, Delaney, Aidan and Floridi, Luciano (2018) Theories of signs define a novel approach to the analysis of clinical biomarkers of inflammation and oxidative stress. Proceedings of the National Academy of Sciences, 115 (10). pp. 2473-2477. ISSN 0027-8424

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Abstract

Biomarkers are widely used not only as prognostic or diagnostic indicators, or as surrogate markers of disease in clinical trials, but also to formulate theories of pathogenesis. We identify two problems in the use of biomarkers in mechanistic studies. The first problem arises in the case of multifactorial diseases, where different combinations of multiple causes result in patient heterogeneity. The second problem arises when a pathogenic mediator is difficult to measure. This is the case of the oxidative stress (OS) theory of disease where the causal components are reactive oxygen species (ROS) that have very short half-lives. In this case, it is usual measure the traces left by the reaction of ROS with biological molecules, rather than the ROS themselves. Borrowing from the philosophical theories of signs, we look at the different facets of biomarkers and discuss their different value and meaning in multifactorial diseases and system medicine, to inform their use in patient stratification in personalized medicine.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine
Depositing User: Pietro Ghezzi
Date Deposited: 21 Feb 2018 14:55
Last Modified: 20 Aug 2018 01:00
URI: http://sro.sussex.ac.uk/id/eprint/73142

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