Non-fatal disease burden for subtypes of depressive disorder: population-based epidemiological study

Biesheuvel-Leliefeld, Karolien E M, Kok, Gemma D, Bockting, Claudi L H, de Graaf, Ron, ten Have, Margaret, van der Horst, Henriette E, van Schaik, Anneke, van Marwijk, Harm W J and Smit, Filip (2016) Non-fatal disease burden for subtypes of depressive disorder: population-based epidemiological study. BMC Psychiatry, 16 (1). ISSN 1471-244X

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Abstract

Background: Major depression is the leading cause of non-fatal disease burden. Because major depression is not a homogeneous condition, this study estimated the non-fatal disease burden for mild, moderate and severe depression in both single episode and recurrent depression. All estimates were assessed from an individual and a population perspective and presented as unadjusted, raw estimates and as estimates adjusted for comorbidity. Methods: We used data from the first wave of the second Netherlands-Mental-Health-Survey-and-Incidence-Study (NEMESIS-2, n = 6646; single episode Diagnostic and Statistical Manual (DSM)-IV depression, n = 115; recurrent depression, n = 246). Disease burden from an individual perspective was assessed as 'disability weight * time spent in depression' for each person in the dataset. From a population perspective it was assessed as 'disability weight * time spent in depression *number of people affected'. The presence of mental disorders was assessed with the Composite International Diagnostic Interview (CIDI) 3.0. Results: Single depressive episodes emerged as a key driver of disease burden from an individual perspective. From a population perspective, recurrent depressions emerged as a key driver. These findings remained unaltered after adjusting for comorbidity. Conclusions: The burden of disease differs between the subtype of depression and depends much on the choice of perspective. The distinction between an individual and a population perspective may help to avoid misunderstandings between policy makers and clinicians. © 2016 Biesheuvel-Leliefeld et al.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Depositing User: Rosie Harvey
Date Deposited: 11 Jan 2018 14:52
Last Modified: 11 Jan 2018 14:52
URI: http://sro.sussex.ac.uk/id/eprint/72755

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