Longitudinal associations of multiple physical symptoms with recurrence of depressive and anxiety disorders

Dijkstra-Kersten, Sandra M A, Sitnikova, Kate, Terluin, Berend, Penninx, Brenda W J H, Twisk, Jos W R, van Marwijk, Harm W J, van der Horst, Henriette E, van der Wouden, Johannes C and Unset (2017) Longitudinal associations of multiple physical symptoms with recurrence of depressive and anxiety disorders. Journal of Psychosomatic Research, 97. pp. 96-101. ISSN 0022-3999

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Abstract

Objective
To examine longitudinal associations of multiple physical symptoms with recurrence of depressive and anxiety disorders.

Methods
Follow-up data of 584 participants with remitted depressive or anxiety disorders were used from the Netherlands Study of Depressive and Anxiety disorders. Multiple physical symptoms were measured at baseline (T1) and two-year follow-up (T2) by the Four-Dimensional Symptom Questionnaire (4DSQ) somatization subscale. Recurrence of depressive and anxiety disorders was assessed at two-year (T2) and four-year (T4) follow-up with the Composite International Diagnostic Interview. Logistic Generalized Estimating Equations were used to examine associations of multiple physical symptoms with recurrence of depressive and anxiety disorders. Depressive (IDS-SR) and anxiety symptoms (BAI), and other relevant covariates were taken into account.

Results
Multiple physical symptoms were significantly associated with recurrence of depression (OR = 1.04, 95%CI = 1.00–1.08), anxiety (OR = 1.07, 95%CI = 1.03–1.12), and depressive or anxiety disorders (OR = 1.06, 95%CI = 1.02–1.10), on average over time. Odds ratios did not change substantially when the IDS-SR mood-cognition and BAI subjective scale were included as covariates.

Conclusion
The presence of multiple physical symptoms was positively related to recurrence of depressive and anxiety disorders, independent of depressive and anxiety symptoms. Knowledge of risk factors for recurrence of depressive and anxiety disorders, such as the presence of multiple physical symptoms, could provide possibilities for better targeting interventions to prevent recurrence.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Primary Care and Public Health
Depositing User: Rosie Harvey
Date Deposited: 12 Jan 2018 08:03
Last Modified: 24 Apr 2018 01:00
URI: http://sro.sussex.ac.uk/id/eprint/72743

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