University of Sussex
Browse
10.1007%2Fs11136-017-1536-2.pdf (916.1 kB)

Utility scores for different health states related to depression: individual participant data analysis

Download (916.1 kB)
journal contribution
posted on 2023-06-21, 06:02 authored by Spyros Kolovos, Judith E Bosmans, Johanna M van Dongen, Birre van Esveld, Dorcas Magai, Annemieke van Straten, Christina van der Feltz-Cornelis, Kirsten M van Steenbergen-Weijenburg, Klaas M Huijbregts, Harm van MarwijkHarm van Marwijk, Heleen Riper, Maurits W van Tulder
OBJECTIVES: Depression is associated with considerable impairments in health-related quality-of-life. However, the relationship between different health states related to depression severity and utility scores is unclear. The aim of this study was to evaluate whether utility scores are different for various health states related to depression severity. METHODS: We gathered individual participant data from ten randomized controlled trials evaluating depression treatments. The UK EQ-5D and SF-6D tariffs were used to generate utility scores. We defined five health states that were proposed from American Psychiatric Association and National Institute for Clinical Excellence guidelines: remission, minor depression, mild depression, moderate depression, and severe depression. We performed multilevel linear regression analysis. RESULTS: We included 1629 participants in the analyses. The average EQ-5D utility scores for the five health states were 0.70 (95% CI 0.67-0.73) for remission, 0.62 (95% CI 0.58-0.65) for minor depression, 0.57 (95% CI 0.54-0.61) for mild depression, 0.52 (95%CI 0.49-0.56) for moderate depression, and 0.39 (95% CI 0.35-0.43) for severe depression. In comparison with the EQ-5D, the utility scores based on the SF-6D were similar for remission (EQ-5D?=?0.70 vs. SF-6D?=?0.69), but higher for severe depression (EQ-5D?=?0.39 vs. SF-6D?=?0.55). CONCLUSIONS: We observed statistically significant differences in utility scores between depression health states. Individuals with less severe depressive symptoms had on average statistically significant higher utility scores than individuals suffering from more severe depressive symptomatology. In the present study, EQ-5D had a larger range of values as compared to SF-6D.

History

Publication status

  • Published

File Version

  • Published version

Journal

Quality of Life Research

ISSN

0962-9343

Publisher

Springer

Issue

7

Volume

26

Page range

1649-1658

Department affiliated with

  • Primary Care and Public Health Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2018-01-12

First Open Access (FOA) Date

2018-01-12

First Compliant Deposit (FCD) Date

2018-01-11

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC