Interoception and inflammation in psychiatric disorders

Savitz, Jonathan and Harrison, Neil (2018) Interoception and inflammation in psychiatric disorders. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. ISSN 2451-9022 (Accepted)

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Abstract

Despite a historical focus on neurally-mediated interoceptive signaling mechanisms, humoral (and even cellular) signals also play an important role in communicating bodily physiological state to the brain. These signaling pathways can perturb neuronal structure, chemistry and function leading to discrete changes in behavior. They are also increasingly implicated in the pathophysiology of psychiatric disorders. The importance of these humoral signaling pathways is perhaps most powerfully illustrated in the context of infection and inflammation. Here we provide an overview of how immune activation of neural and humoral interoceptive mechanisms interact to mediate discrete changes in brain and behavior and highlight how activation of these pathways at specific points in neural development may predispose to psychiatric disorder. As our mechanistic understanding of these interoceptive pathways continues to emerge it is revealing novel therapeutic targets, potentially heralding an exciting new era of immunotherapies in psychiatry.

Item Type: Article
Keywords: Autism, Cytokine, Depression, fMRI, Imaging, Inflammation, Insula, Interoception, Schizophrenia
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Research Centres and Groups: Sackler Centre for Consciousness Science
Depositing User: Alexei Fisk
Date Deposited: 05 Jan 2018 10:11
Last Modified: 05 Jan 2018 11:40
URI: http://sro.sussex.ac.uk/id/eprint/72620

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Mechanisms of Human SicknessG0043WELLCOME TRUST093881/Z/10/Z