Fury_2014_J._Phys.__Conf._Ser._498_012002.pdf (3.8 MB)
Laser vibrometry characterisation of a microfluidic lab-on-a-chip device: a preliminary investigation
journal contribution
posted on 2023-06-21, 06:02 authored by C Fury, P N Gélat, P H Jones, G MemoliSince their original inception as ultrasound contrast agents, potential applications of microbubbles have evolved to encompass molecular imaging and targeted drug delivery. As these areas develop, so does the need to understand the mechanisms behind the interaction of microbubbles both with biological tissue and with other microbubbles. There is therefore a metrological requirement to develop a controlled environment in which to study these processes. Presented here is the design and characterisation of such a system, which consists of a microfluidic chip, specifically developed for manipulating microbubbles using both optical and acoustic trapping. A laser vibrometer is used to observe the coupling of acoustic energy into the chip from a piezoelectric transducer bonded to the surface. Measurement of the velocity of surface waves on the chip is investigated as a potential method for inferring the nature of the acoustic fields excited within the liquid medium of the device. Comparison of measured surface wavelengths with wave types suggests the observation of anti-symmetric Lamb or Love-Kirchhoff waves. Further visual confirmation of the acoustic fields through bubble aggregation highlights differences between the model and experimental results in predicting the position of acoustic pressure nodes in relation to excitation frequency.
History
Publication status
- Published
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- Published version
Journal
Journal of Physics: Conference SeriesISSN
1742-6588Publisher
IOP PublishingExternal DOI
Issue
1Volume
498Page range
012002Department affiliated with
- Informatics Publications
Research groups affiliated with
- Creative Technology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2018-01-02First Open Access (FOA) Date
2018-01-02First Compliant Deposit (FCD) Date
2018-01-02Usage metrics
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