Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination

Streitz, Mathias, Fuhrmann, Stephan, Powell, Fiona, Quassem, Ali, Nomura, Laurel, Maecker, Holden, Martus, Peter, Volk, Hans-Dieter and Kern, Florian (2011) Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination. Journal of Infectious Diseases, 203 (3). pp. 378-382. ISSN 0022-1899

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Abstract

Functional characteristics of tuberculosis (TB)-specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon gamma [IFN-gamma], tumor necrosis factor alpha [TNF-alpha], and interleukin 2 [IL-2\ production). Interestingly, CD154 up-regulation accounted for similar to 80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-gamma accounted for only similar to 50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-gamma production alone.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: Q Science > QR Microbiology
Q Science > QR Microbiology > QR0180 Immunology
R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases
Depositing User: Grecia GarciaGarcia
Date Deposited: 17 Aug 2011 10:30
Last Modified: 03 Jul 2012 14:27
URI: http://sro.sussex.ac.uk/id/eprint/7241
Google Scholar:3 Citations
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