A pilot study on brain plasticity of functional connectivity modulated by cognitive training in mild Alzheimer's disease and mild cognitive impairment

Barban, Francesco, Mancini, Matteo, Cercignani, Mara, Adriano, Fulvia, Perri, Roberta, Annicchiarico, Roberta, Carlesimo, Giovanni Augusto, Ricci, Claudia, Lombardi, Maria Giovanna, Teodonno, Valeria, Serra, Laura, Giulietti, Giovanni, Fadda, Lucia, Federici, Alessia, Caltagirone, Carlo and Bozzali, Marco (2017) A pilot study on brain plasticity of functional connectivity modulated by cognitive training in mild Alzheimer's disease and mild cognitive impairment. Brain Sciences, 7 (5). ISSN 2076-3425

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Abstract

Alzheimer's disease (AD) alters the functional connectivity of the default mode network (DMN) but also the topological properties of the functional connectome. Cognitive training (CT) is a tool to slow down AD progression and is likely to impact on functional connectivity. In this pilot study, we aimed at investigating brain functional changes after a period of CT and active control (AC) in a group of 26 subjects with mild AD (mAD), 26 with amnestic mild cognitive impairment (aMCI), and a control group of 29 healthy elderly (HE) people. They all underwent a CT and AC in a counterbalanced order following a crossover design. Resting-state functional MRI and neuropsychological testing were acquired before and after each period. We tested post-CT and post-AC changes of cognitive abilities, of the functional connectivity of the DMN, and of topological network properties derived from graph theory and network-based statistics. Only CT produced functional changes, increasing the functional connectivity of the posterior DMN in all three groups. mAD also showed functional changes in the medial temporal lobe and topological changes in the anterior cingulum, whereas aMCI showed more widespread topological changes involving the frontal lobes, the cerebellum and the thalamus. Our results suggest specific functional connectivity changes after CT for aMCI and mAD.

Item Type: Article
Keywords: Alzheimer’s disease; mild cognitive impairment; neural plasticity; DMN; connectomics; fMRI; graph theory; cognitive training
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0438 Psychiatry > RC0512 Psychopathology > RC0513 Psychoses > RC0521 Dementia > RC0522 Presenile dementia > RC0523 Alzheimer's disease
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Depositing User: Patricia Butler
Date Deposited: 20 Dec 2017 14:17
Last Modified: 15 Jan 2018 09:50
URI: http://sro.sussex.ac.uk/id/eprint/72349

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