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Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands

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posted on 2023-06-09, 09:25 authored by Supojjanee Sansook, Wei Tuo, Mélanie Bollier, Amélie Barczyk, Xavier Dezitter, Fredérique Klupsch, Natascha Leleu-Chavain, Amaury Farce, Graham J Tizzard, Simon J Coles, John SpencerJohn Spencer, Regis Millet
Ferrocene analogues of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically. The resulting bioorganometallic isoxazoles were assayed for their effects on CB1 and CB2 receptors as well as on FAAH. None had any FAAH activity but compound 3, 5-(2-(pentyloxy)phenyl)-N-ferrocenylisoxazole- 3-carboxamide, was found to be a potent CB2 ligand (Ki = 32.5 nM).

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Future Medicinal Chemistry

ISSN

1756-8919

Publisher

Future Science

Issue

6

Volume

10

Page range

631-638

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-12-18

First Open Access (FOA) Date

2019-02-08

First Compliant Deposit (FCD) Date

2017-12-17

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