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Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2
journal contribution
posted on 2023-06-07, 16:05 authored by Thorsten Thye, Fredrik O. Vannberg, Sunny H. Wong, Ellis Owusu-Dabo, Ivy Osei, John Gyapong, Giorgio Sirugo, Fatou Sisay-Joof, Anthony Enimil, Margaret A. Chinbuah, Sian Floyd, David K. Warndorff, Lifted Sichali, Simon Malema, Amelia C. Crampin, Bagrey Ngwira, Yik Y. Teo, Kerrin Small, Kirk Rockett, Dominic Kwiatkowski, Paul E. Fine, Philip C. Hill, Melanie NewportMelanie Newport, Christian Lienhardt, Richard A. Adegbola, Tumani Corrah, Andreas Ziegler, Andrew P. Morris, Christian G. Meyer, Rolf D. Horstmann, Adrian V. S. HillWe combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
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Publication status
- Published
Journal
Nature GeneticsISSN
1061-4036Publisher
Nature Publishing GroupExternal DOI
Issue
9Volume
42Page range
739-741Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2011-08-16Usage metrics
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