Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Thye, Thorsten, Vannberg, Fredrik O., Wong, Sunny H., Owusu-Dabo, Ellis, Osei, Ivy, Gyapong, John, Sirugo, Giorgio, Sisay-Joof, Fatou, Enimil, Anthony, Chinbuah, Margaret A., Floyd, Sian, Warndorff, David K., Sichali, Lifted, Malema, Simon, Crampin, Amelia C., Ngwira, Bagrey, Teo, Yik Y., Small, Kerrin, Rockett, Kirk, Kwiatkowski, Dominic, Fine, Paul E., Hill, Philip C., Newport, Melanie J., Lienhardt, Christian, Adegbola, Richard A., Corrah, Tumani, Ziegler, Andreas, Morris, Andrew P., Meyer, Christian G., Horstmann, Rolf D. and Hill, Adrian V. S. (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature Genetics, 42 (9). pp. 739-741. ISSN 1061-4036

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Abstract

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics
Depositing User: Grecia GarciaGarcia
Date Deposited: 16 Aug 2011 09:27
Last Modified: 30 Nov 2012 16:55
URI: http://sro.sussex.ac.uk/id/eprint/7221
Google Scholar:31 Citations
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