Unexpected antimicrobial effect of statins

Jerwood, S. and Cohen, Jonathan (2008) Unexpected antimicrobial effect of statins. Journal of Antimicrobial Chemotherapy, 61 (2). pp. 362-364. ISSN 0305-7453

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Abstract

Objectives: Epidemiological studies of statins have suggested a link between statin therapy and a decreased risk of sepsis. It has been proposed that the mechanism underlying this apparent protective effect of statins relates to their known immunomodulatory and anti-inflammatory effects. The aim of this study was to explore the antimicrobial effect of statins.

Methods: Simvastatin (Merck) and fluvastatin (Novartis) were both tested against six of each of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA + MRSA), and vancomycin-sensitive and -resistant enterococci (VSE + VRE) using a microtitre dilution method. The test was repeated five times for both statins against all 24 isolates. Vancomycin, linezolid and propranolol were used as controls, as appropriate.

Results and discussion: Simvastatin showed a significant antimicrobial effect against MSSA (mean MIC 29.2 mg/L) and to a lesser extent against MRSA (mean MIC 74.9 mg/L). Fluvastatin had a significantly less marked antimicrobial effect. Propranolol showed no antimicrobial effect. Simvastatin has a considerable antimicrobial effect in vitro and further testing of it is warranted.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: Q Science > QR Microbiology
R Medicine > RC Internal medicine > RC0109 Infectious and parasitic diseases
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Depositing User: Grecia GarciaGarcia
Date Deposited: 15 Aug 2011 11:03
Last Modified: 30 Nov 2012 16:55
URI: http://sro.sussex.ac.uk/id/eprint/7210
Google Scholar:28 Citations
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