Sepsis: Time to reconsider the concept

Carlet, Jean, Cohen, Jonathan, Calandra, Thierry, Opal, Steven M. and Masur, Henry (2008) Sepsis: Time to reconsider the concept. Critical Care Medicine, 36 (3). pp. 964-966. ISSN 0090-3493

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Abstract

Objective: To discuss the difficulty in using the concept of sepsis for clinical trials and propose new ways for designing future trials for severe infections.

Design: Short position statement.

Methods and Main Research: Using a thorough evaluation of the recent literature in the field of severe sepsis and septic shock, the authors challenge the concept of sepsis as used in the past two decades and propose new ideas for designing future trials in this setting. The two main proposals are first to use a systematic assessment of the targeted inflammatory mediators when the study intends to counteract or replace those mediators (e.g., anti-tumor necrosis factor-[alpha], activated protein C) and, second, to select more homogeneous populations, coming back to "precise infectious diseases," such as severe community-acquired pneumonia, severe peritonitis, or meningitis.

Conclusions: The concept of sepsis has been useful to help clinicians to suspect and detect severe infections. Due to a considerable heterogeneity in the patients and type of infections included in the trials performed in the last two decades, it has not been useful in demonstrating the efficacy of new compounds. The authors propose a dramatic change in the design of future trials dealing with severe infections.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
Depositing User: Grecia GarciaGarcia
Date Deposited: 15 Aug 2011 10:55
Last Modified: 01 Sep 2017 10:15
URI: http://sro.sussex.ac.uk/id/eprint/7209
Google Scholar:44 Citations
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