Eccles, Jessica, Lallemant, Camille, Mushtaq, Farrah, Greenwood, Matthew, Keller, Majella, Golding, Bruno, Tibble, Jeremy, Haq, Inam and Whale, Richard (2012) Pre-treatment waking cortisol response and vulnerability to interferon α induced depression. European Neuropsychopharmacology, 22 (12). pp. 892-896. ISSN 0924-977XFull text not available from this repository.
Depressive disorder is a common consequence of interferon α treatment. An understanding of the aetiological processes involved is evolving. HPA axis abnormalities are clearly described in community depressive disorder and represent vulnerability to depression development. We explored whether pre-treatment HPA axis abnormalities influence depression emergence during interferon α treatment. We examined waking HPA axis response via salivary cortisol sampling in 44 non-depressed, chronic hepatitis C infected patients due to commence standard interferon α treatment. Hamilton depression scales and the structured clinical interview for DSM-IV major depressive disorder status were administered monthly during treatment. Major depressive disorder developed in 26 of 44 subjects during interferon-α treatment. The pre-treatment waking cortisol response over 1h was significantly greater in the subsequent switch to depression group (F=4.23, p=0.046). The waking cortisol response pre-treatment with interferon α appears greater in those subsequently switching to depressive disorder during treatment. This waking response may join other vulnerability factors for depression emergence in this group. This model could prove a valuable tool in understanding non-iatrogenic depressive disorder in the general population and notably the role of cytokines.
|Additional Information:||Impact Factor: 4.046|
|Keywords:||Depression; Aetiology; HPA axis; Interferon; Cytokines; Hepatitis C virus; Neuroendocrinology; Serotonin|
|Schools and Departments:||Brighton and Sussex Medical School > Clinical Medicine|
|Subjects:||R Medicine > RM Therapeutics. Pharmacology|
|Depositing User:||Grecia GarciaGarcia|
|Date Deposited:||31 Jul 2012 09:28|
|Last Modified:||02 Dec 2012 19:55|