In search of biologic correlates for liver texture on portal-phase CT

Ganeshan, Balaji, Miles, Kenneth A., Young, Rupert and Chatwin, Chris (2007) In search of biologic correlates for liver texture on portal-phase CT. Academic Radiology, 14 (9). pp. 1058-1068. ISSN 1076-6332

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Abstract

Rationale and Objectives. The acceptance of computer-assisted diagnosis (CAD) in clinical practice has been constrained by the scarcity of identifiable biologic correlates for CAD-based image parameters. This study aims to identify biologic correlates for computed tomography (CT) liver texture in a series of patients with colorectal cancer.

Materials and Methods. In 28 patients with colorectal cancer, total hepatic perfusion (THP), hepatic arterial perfusion, and hepatic portal perfusion (HPP) were measured using perfusion CT. Hepatic glucose use was also determined from positron emission tomography (PET) and expressed as standardized uptake value (SUV). A hepatic phosphorylation fraction index (HPFI) was determined from both SUV and THP. These physiologic parameters were correlated with CAD parameters namely hepatic densitometry, selective-scale, and relative-scale texture features in apparently normal areas of portal-phase hepatic CT.

Results. For patients without liver metastases, a relative-scale texture parameter correlated inversely with SUV (r = -0.587, P =.007) and, positively with THP (r = 0.512, P =.021) and HPP (r = 0.451, P =.046). However, this relative texture parameter correlated most significantly with HPFI (r = -0.590, P =.006). For patients with liver metastases, although not significant an opposite trend was observed between these physiologic parameters and relative texture features (THP: r < -0.4, HPFI: r > 0.35).

Conclusion. Total hepatic blood flow and glucose metabolism are two distinct but related biologic correlates for liver texture on portal phase CT, providing a rationale for the use of hepatic texture analysis as a indicator for patients with colorectal cancer.

Item Type: Article
Schools and Departments: School of Engineering and Informatics > Engineering and Design
School of Mathematical and Physical Sciences > Mathematics
Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
Depositing User: Grecia GarciaGarcia
Date Deposited: 10 Aug 2011 10:21
Last Modified: 01 Sep 2017 10:15
URI: http://sro.sussex.ac.uk/id/eprint/7179
Google Scholar:13 Citations
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