Ganeshan, Balaji, Miles, Kenneth A., Young, Rupert and Chatwin, Chris (2007) Hepatic enhancement in colorectal cancer: Texture analysis correlates with hepatic hemodynamics and patient survival. Academic Radiology, 14 (12). pp. 1520-1530. ISSN 1076-6332Full text not available from this repository.
Rationale and Objectives. Perfusion imaging of the liver has attracted interest as a potential means for earlier detection of hepatic metastases, but the techniques are complex and do not form part of routine imaging protocols. This study assesses whether the hemodynamic status of the liver of patients with colorectal cancer but apparently normal hepatic morphology is reflected by texture features within a single portal-phase contrast enhanced computed tomography (CT) image and correlates texture with overall survival.
Materials and Methods. Portal-phase CT images from 27 patients with colorectal cancer but no apparent hepatic metastases were processed using a band-pass filter that highlighted image features at different spatial frequencies. A rang of parameters C C, e reflecting liver texture on filtered images were correlated against CT hepatic perfusion index (HPI) and patient survival.
Results. After image filtration, entropy values from hepatic regions were inversely correlated with HPI (r = -0.503978, t, P =.007355), and directly correlated with survival (r = 0.489642, P =.009533). An entropy value below 2.0 identified four patients who died within 36 months of their CT scan with sensitivity 100% and specificity 65% (P <.03).
Conclusion. The hemodynamic status of the liver is reflected by subtle changes in coarse texture on portal phase images C, that can be revealed by texture analysis. Texture analysis has the potential to identify colorectal cancer patients with an apparently normal portal phase hepatic CT but reduced survival.
|Schools and Departments:||School of Engineering and Informatics > Engineering and Design
School of Mathematical and Physical Sciences > Mathematics
Brighton and Sussex Medical School > Clinical and Laboratory Investigation
|Subjects:||R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine|
|Depositing User:||Grecia GarciaGarcia|
|Date Deposited:||10 Aug 2011 10:06|
|Last Modified:||30 Nov 2012 16:55|
|Google Scholar:||13 Citations|