Ganeshan, Balaji, Miles, Kenneth A., Young, Rupert and Chatwin, Chris (2009) Texture analysis in non-contrast enhanced CT: Impact of malignancy on texture in apparently disease-free areas of the liver. European Journal of Radiology, 70 (1). pp. 101-110. ISSN 0720-048XFull text not available from this repository.
Objectives: To determine whether texture analysis of non-contrast enhanced computed tomography (CT) images in apparently disease-free areas of the liver is altered by the presence of extra- and intra-hepatic malignancy in colorectal cancer patients.
Materials and methods: Hepatic attenuation and texture were assessed from non-contrast enhanced CT in three groups of colorectal cancer patients: (A) 15 controls with no malignancy; (B) nine patients with extra-hepatic malignancy but no liver involvement; (C) eight patients with hepatic metastases. Regions of interest were manually constructed only over apparently normal areas of liver tissue excluding major blood vessels and areas of intra-hepatic fat, which may otherwise alter CT texture irrespective of the presence of malignancy. Texture was analysed on unfiltered images and following band-pass image filtration to highlight image features at different spatial frequencies (fine: 2 pixels/1.68 mm in width, medium: 6 pixels/5.04 mm and coarse: 12 pixels/10.08 mm). The relative contributions made to the image by features at two different spatial frequencies were expressed as filter ratios (fine/medium, fine/coarse and medium/coarse). Texture was quantified as mean grey-level intensity, entropy and uniformity.
Results: Texture was not altered on unfiltered images whereas relative texture analysis following image filtration identified differences in fine to medium texture ratios in apparently disease-free areas of the liver in patients with hepatic metastases as compared to patients with no tumour (entropy, p = 0.0257) and patients with extra-hepatic disease (uniformity, p = 0.0143).
Conclusions: Relative texture analysis of unenhanced hepatic CT can reveal changes in apparently disease-free areas of the liver that have previously required more complex perfusion measurements for detection.
|Schools and Departments:||School of Engineering and Informatics > Engineering and Design
School of Mathematical and Physical Sciences > Mathematics
Brighton and Sussex Medical School > Clinical and Laboratory Investigation
|Subjects:||R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine|
|Depositing User:||Grecia GarciaGarcia|
|Date Deposited:||10 Aug 2011 09:59|
|Last Modified:||30 Nov 2012 16:55|
|Google Scholar:||15 Citations|