Texture analysis in non-contrast enhanced CT: Impact of malignancy on texture in apparently disease-free areas of the liver

Ganeshan, Balaji, Miles, Kenneth A, Young, Rupert C D and Chatwin, Chris R (2009) Texture analysis in non-contrast enhanced CT: Impact of malignancy on texture in apparently disease-free areas of the liver. European Journal of Radiology, 70 (1). pp. 101-110. ISSN 0720-048X

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Abstract

Objectives: To determine whether texture analysis of non-contrast enhanced computed tomography (CT) images in apparently disease-free areas of the liver is altered by the presence of extra- and intra-hepatic malignancy in colorectal cancer patients.

Materials and methods: Hepatic attenuation and texture were assessed from non-contrast enhanced CT in three groups of colorectal cancer patients: (A) 15 controls with no malignancy; (B) nine patients with extra-hepatic malignancy but no liver involvement; (C) eight patients with hepatic metastases. Regions of interest were manually constructed only over apparently normal areas of liver tissue excluding major blood vessels and areas of intra-hepatic fat, which may otherwise alter CT texture irrespective of the presence of malignancy. Texture was analysed on unfiltered images and following band-pass image filtration to highlight image features at different spatial frequencies (fine: 2 pixels/1.68 mm in width, medium: 6 pixels/5.04 mm and coarse: 12 pixels/10.08 mm). The relative contributions made to the image by features at two different spatial frequencies were expressed as filter ratios (fine/medium, fine/coarse and medium/coarse). Texture was quantified as mean grey-level intensity, entropy and uniformity.

Results: Texture was not altered on unfiltered images whereas relative texture analysis following image filtration identified differences in fine to medium texture ratios in apparently disease-free areas of the liver in patients with hepatic metastases as compared to patients with no tumour (entropy, p = 0.0257) and patients with extra-hepatic disease (uniformity, p = 0.0143).

Conclusions: Relative texture analysis of unenhanced hepatic CT can reveal changes in apparently disease-free areas of the liver that have previously required more complex perfusion measurements for detection.

Item Type: Article
Schools and Departments: School of Engineering and Informatics > Engineering and Design
School of Mathematical and Physical Sciences > Mathematics
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
Depositing User: Grecia GarciaGarcia
Date Deposited: 10 Aug 2011 09:59
Last Modified: 05 Oct 2017 18:26
URI: http://sro.sussex.ac.uk/id/eprint/7177
Google Scholar:15 Citations
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