Ganeshan, Balaji, Miles, Kenneth A., Young, Rupert, Chatwin, Chris, Gurling, Hugh M. D. and Critchley, Hugo D. (2010) Three-dimensional textural analysis of brain images reveals distributed grey-matter abnormalities in schizophrenia. European Radiology, 20 (4). pp. 941-948. ISSN 0938-7994Full text not available from this repository.
Three-dimensional (3-D) selective- and relative-scale texture analysis (TA) was applied to structural magnetic resonance (MR) brain images to quantify the presence of grey-matter (GM) and white-matter (WM) textural abnormalities associated with schizophrenia.
Brain TA comprised volume filtration using the Laplacian of Gaussian filter to highlight fine, medium and coarse textures within GM and WM, followed by texture quantification. Relative TA (e.g. ratio of fine to medium) was also computed. T1-weighted MR whole-brain images from 32 participants with diagnosis of schizophrenia (n = 10) and healthy controls (n = 22) were examined. Five patients possessed marker alleles (SZ8) associated with schizophrenia on chromosome 8 in the pericentriolar material 1 gene while the remaining five had not inherited any of the alleles (SZ0).
Filtered fine GM texture (mean grey-level intensity; MGI) most significantly differentiated schizophrenic patients from controls (P = 0.0058; area under the receiver-operating characteristic curve = 0.809, sensitivity = 90%, specificity = 70%). WM measurements did not distinguish the two groups. Filtered GM and WM textures (MGI) correlated with total GM and WM volume respectively. Medium-to-coarse GM entropy distinguished SZ0 from controls (P = 0.0069) while measures from SZ8 were intermediate between the two.
3-D TA of brain MR enables detection of subtle distributed morphological features associated with schizophrenia, determined partly by susceptibility genes.
|Schools and Departments:||School of Engineering and Informatics > Engineering and Design
School of Mathematical and Physical Sciences > Mathematics
Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Brighton and Sussex Medical School > Clinical Medicine
|Subjects:||R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine|
|Depositing User:||Grecia GarciaGarcia|
|Date Deposited:||10 Aug 2011 09:34|
|Last Modified:||30 Nov 2012 16:55|
|Google Scholar:||6 Citations|