Deletion variant of alpha 2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance

Gibbs, Ayana A., Naudts, Kris H., Azevedo, Ruben T. and David, Anthony S. (2010) Deletion variant of alpha 2b-adrenergic receptor gene moderates the effect of COMT val(158)met polymorphism on episodic memory performance. European Neuropsychopharmacology, 20 (4). pp. 272-275. ISSN 0924-977X

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Abstract

The COMT val(158) variant has been associated with impaired cognitive function compared to the Met(158) variant yet gene gene interactions are not well described. In this study we demonstrate an interaction between this COMT polymorphism and a deletion variant of ADRA2B, the gene encoding the alpha 2b-adrenergic receptor on episodic memory performance. Specifically, carriage of the ADRA2B deletion abolished the relative memory impairment in homozygous COMT val(158) carriers compared to Met(158) carriers.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
?? RC0435 ??
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Depositing User: Grecia GarciaGarcia
Date Deposited: 09 Aug 2011 10:29
Last Modified: 18 Jul 2012 15:02
URI: http://sro.sussex.ac.uk/id/eprint/7169
Google Scholar:3 Citations
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