Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study

Governo, R J M, Morris, P G, Marsden, C A and Chapman, V (2008) Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study. British Journal of Pharmacology, 153 (7). pp. 1558-1567. ISSN 0007-1188

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Abstract

Random effect analysis revealed that the lower dose of GBP produced significant (P<0.001) increases in BOLD signal intensity in several brain regions, including the thalamus and periaqueductal grey (PAG), compared to basal. This dose of GBP also produced significant (P<0.001) decreases in BOLD signal intensity in the amygdala and the entorhinal cortex. Increasing the dose of GBP (100 mg kg(-1)) produced significantly greater changes in BOLD signal intensity in several brain regions including the thalamus and PAG. MAP was not significantly altered by GBP, compared to saline.Conclusions and implications: GBP had marked positive and negative effects on BOLD signal intensity in a number of brain regions in naïve rats. The activation of key areas involved in nociceptive processing indicate a supraspinal site of action of GBP and this may contribute to its well-described analgesic effects in animal models of pain and clinical studies.

Item Type: Article
Additional Information: IDS Number: 282HY
Keywords: CHANNEL ALPHA(2)DELTA SUBUNITS; RANDOMIZED CONTROLLED-TRIAL; GAMMA-AMINOBUTYRIC-ACID; NEUROPATHIC PAIN MODEL; CALCIUM-CHANNEL; PERIAQUEDUCTAL GRAY; DORSAL-HORN; POSTHERPETIC NEURALGIA; INTRATHECAL GABAPENTIN; CENTRAL SENSITIZATION
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: R Medicine > RC Internal medicine
R Medicine > RM Therapeutics. Pharmacology
Depositing User: Tracey O'Gorman
Date Deposited: 24 Aug 2011 15:03
Last Modified: 17 Jun 2013 15:46
URI: http://sro.sussex.ac.uk/id/eprint/7156
Google Scholar:8 Citations
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