Tumor–stromal cell communication: small vesicles signal big changes

Wendler, Franz, Stamp, Gordon and Giamas, Georgios (2016) Tumor–stromal cell communication: small vesicles signal big changes. Trends in Cancer, 2 (7). pp. 326-329. ISSN 2405-8033

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Abstract

Reciprocal interactions between malignant and stromal cells create a local microenvironment that fosters tumor growth. Extracellular vesicles (EVs) such as exosomes, microvesicles, and large oncosomes are involved in tumor–stroma communication by shuttling signaling cargo and other molecules. Here we discuss how EVs released by cancer or stromal cells impact the proliferation, differentiation, and metabolism of tumors.

Item Type: Article
Keywords: Exosomes; Tumour microenvironment; cancer; cell signalling
Schools and Departments: School of Life Sciences > Biochemistry
Subjects: Q Science
Depositing User: Georgios Giamas
Date Deposited: 23 Nov 2017 09:58
Last Modified: 23 Nov 2017 10:31
URI: http://sro.sussex.ac.uk/id/eprint/71501

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