Ways and means of eukaryotic mRNA decay

Balagopal, Vidya, Fluch, Lydia and Nissan, Tracy (2012) Ways and means of eukaryotic mRNA decay. Biochimica et Biophysica Acta, 1819 (6). pp. 593-603. ISSN 0006-3002

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Abstract

Messenger RNA degradation is an important point of control for gene expression. Genome-wide studies on mRNA stability have demonstrated its importance in adaptation and stress response. Most of the key players in mRNA decay appear to have been identified. The study of these proteins brings insight into the mechanism of general and specific targeting of transcripts for degradation. Recruitment and assembly of mRNP complexes enhance and bring specificity to mRNA decay. mRNP complexes can form larger structures that have been found to be ubiquitous in nature. Discovery of P-Bodies, an archetype of this sort of aggregates, has generated interest in the question of where mRNA degrades. This is currently an open question under extensive investigation. This review will discuss in detail the recent developments in the regulation of mRNA decay focusing on yeast as a model system. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
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Depositing User: Tracy Nissan
Date Deposited: 17 Nov 2017 15:32
Last Modified: 26 Jan 2018 12:48
URI: http://sro.sussex.ac.uk/id/eprint/71350

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