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A model for chromosome condensation based on the interplay between condensin and topoisomerase II
The compaction of chromatin that occurs when cells enter mitosis is probably the most iconic process of dividing cells. Mitotic chromosomal compaction or ‘condensation’ is functionally linked to resolution of chromosomal intertwines, transcriptional shut-off and complete segregation of chromosomes. At present, understanding of the molecular events required to convert interphase chromatin into mitotic chromosomes is limited. Here, we review recent advances in the field, focusing on potential chromosomal compaction mechanisms and their importance to chromosome segregation. We propose a model of how metaphase chromosomes could be shaped based on the enzymatic activities of condensin and topoisomerase II in overwinding and relaxation of the DNA fiber during mitosis. We suggest that condensin overwinding is an important requirement for intertwine resolution by topoisomerase II and, together with the inhibition of transcription, contributes to cytological mitotic chromosome appearance or ‘condensation’
Funding
Understanding the mechanisms of termination of DNA replication in eukaryotes Fellow: Baxter; G0222; ROYAL SOCIETY; UO090655
History
Publication status
- Published
Journal
Trends in GeneticsISSN
0168-9525Publisher
ElsevierExternal DOI
Issue
3Volume
28Page range
110-117Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Research groups affiliated with
- Genome Damage and Stability Centre Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2017-11-15Usage metrics
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