Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism

Coppo, Lucia and Ghezzi, Pietro (2011) Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism. Biochemical Society Transactions, 39. pp. 1268-1272. ISSN 0300-5127

Full text not available from this repository.

Abstract

Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, while several cytokine inhibitors have been approved for drug use in chronic inflammatory diseases, this has not happened with antioxidant molecules. We outline the complexity of the role protein thiol-disulfide oxidoreduction in the regulation of immunity and inflammation, the underlying molecular mechanisms (such as protein glutathionylation) and the key enzyme players such as Trx (thioredoxin) or Grx (glutaredoxin).

Item Type: Article
Keywords: cytokine, glutathione, immunity, inflammation, redox regulation, thioredoxin.
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Q Science > QP Physiology > QP0501 Animal biochemistry
Q Science > QR Microbiology > QR0180 Immunology
Depositing User: Pietro Ghezzi
Date Deposited: 17 Apr 2012 10:52
Last Modified: 01 Sep 2017 10:14
URI: http://sro.sussex.ac.uk/id/eprint/7090
📧 Request an update