Coppo, Lucia and Ghezzi, Pietro (2011) Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism. Biochemical Society Transactions, 39. pp. 1268-1272. ISSN 0300-5127Full text not available from this repository.
Inﬂammation or inﬂammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inﬂammatory mediators. However, while several cytokine inhibitors have been approved for drug use in chronic inﬂammatory diseases, this has not happened with antioxidant molecules. We outline the complexity of the role protein thiol-disulﬁde oxidoreduction in the regulation of immunity and inﬂammation, the underlying molecular mechanisms (such as protein glutathionylation) and the key enzyme players such as Trx (thioredoxin) or Grx (glutaredoxin).
|Keywords:||cytokine, glutathione, immunity, inflammation, redox regulation, thioredoxin.|
|Schools and Departments:||Brighton and Sussex Medical School > Clinical and Laboratory Investigation|
|Subjects:||Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
Q Science > QP Physiology > QP0501 Animal biochemistry
Q Science > QR Microbiology > QR0180 Immunology
|Depositing User:||Pietro Ghezzi|
|Date Deposited:||17 Apr 2012 10:52|
|Last Modified:||30 Nov 2012 16:55|