Lung Function in Preschool Children With a History of Wheezing Measured by Forced Oscillation and Plethysmographic Specific Airway Resistance

Harrison, Jo, Gibson, Anne-Marie, Johnson, Khrista, Singh, Gauharjit, Skoric, Billy and Ranganathan, Sarath (2010) Lung Function in Preschool Children With a History of Wheezing Measured by Forced Oscillation and Plethysmographic Specific Airway Resistance. Pediatric Pulmonology, 45 (11). pp. 1049-1056. ISSN 8755-6863

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Abstract

Rationale Wheezing is common in preschool children but objective evidence for airway obstruction and its reversibility are rarely available in clinical practice We assessed whether abnormalities of lung function and bronchodilator response can be detected in preschool children using the forced oscillation technique and measurements of specific airway resistance Methods Fifty nine children with a history of wheeze and 24 healthy controls aged 3-6 years were recruited Resistance and reactance at 6 and 8 Hz (Rrs6 Rrs8 Xrs6 and Xrs8 respectively) were measured using the forced oscillation technique and specific airway resistance was measured in a plethysmograph z Scores were calculated from published reference data Tests were repeated 15 min after 400 mcg salbutamol Bronchodilator response was expressed as the log transformed ratio of postbronchodilator/prebronchodilator values Results Technically acceptable measurements using the forced oscillation technique were obtained in n = 77 (93%) of children and in n = 56 (68%) using plethysmography There was no significant difference in baseline lung function or bronchodilator response assessed by either technique between those with a history of wheeze and healthy controls Conclusion Measurement of lung function is feasible in preschool children but neither of these techniques was able to identify diminished lung function or reversibility to bronchodilator in children with a history of wheeze Pediatr Pulmonol 2010, 45 1049-1056

Item Type: Article
Additional Information: IDS Number: 677WP
Keywords: airway resistance; asthma; bronchodilator response; child; preschool
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: R Medicine > RJ Pediatrics > RJ0101 Child health. Child health services
R Medicine > RJ Pediatrics > RJ0370 Diseases of children and adolescents
Depositing User: Judy Keogh
Date Deposited: 03 Apr 2012 09:26
Last Modified: 30 Nov 2012 16:55
URI: http://sro.sussex.ac.uk/id/eprint/7086
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