Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis

Ranganathan, Sarath C, Parsons, Faith, Gangell, Catherine, Brennan, Siobhan, Stick, Stephen M and Sly, Peter D (2011) Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis. Thorax, 66. pp. 408-413. ISSN 0040-6376

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Abstract

Introduction Improved nutrition is the major proven
benefit of newborn screening programmes for cystic
fibrosis (CF) and is associated with better clinical
outcomes. It was hypothesised that early pulmonary
inflammation and infection in infants with CF is
associated with worse nutrition.
Methods Weight, height and pulmonary inflammation
and infection in bronchoalveolar lavage (BAL) were
assessed shortly after diagnosis in infants with CF and
again at 1, 2 and 3 years of age. Body mass index (BMI)
was expressed as z-scores. Inflammatory cells and
cytokines (interleukin 1b (IL-1b), IL-6, IL-8 and tumour
necrosis factor a (TNFa)), free neutrophil elastase
activity and myeloperoxidase were measured in BAL.
Mixed effects modelling was used to assess longitudinal
associations between pulmonary inflammation,
pulmonary infection (Staphylococcus aureus and
Pseudomonas aeruginosa) and BMI z-score after
adjusting for potential confounding factors.
Results Forty-two infants were studied (16 (38%) male;
39 (93%) pancreatic insufficient); 36 were diagnosed by
newborn screening (at median age 4 weeks) and six by
early clinical diagnosis (meconium ileus). Thirty-one
(74%) received antistaphylococcal antibiotics. More than
two-thirds were asymptomatic at each assessment.
Mean BMI z-scores were

Item Type: Article
Additional Information: IDS Number: 752DD
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: R Medicine > RJ Pediatrics > RJ0101 Child health. Child health services
R Medicine > RJ Pediatrics > RJ0251 Newborn infants Including physiology, care, treatment, diseases
Depositing User: Judy Keogh
Date Deposited: 03 Apr 2012 09:23
Last Modified: 13 Mar 2017 22:54
URI: http://sro.sussex.ac.uk/id/eprint/7084

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