Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages

Waddell, Simon J, Tailleux, Ludovic, Pelizzola, Mattia, Mortellaro, Alessandra, Withers, Michael, Tanne, Antoine, Castagnoli, Paola Ricciardi, Gicquel, Brigitte, Stoker, Neil G, Butcher, Philip D, Foti, Maria and Neyrolles, Olivier (2008) Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages. PLoS ONE, 3 (1). e1403. ISSN 1932-6203

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Abstract

This study provides the proof of principle that probing the host and the microbe transcriptomes simultaneously is a valuable means to accessing unique information on host pathogen interactions. Our results also underline the extraordinary plasticity of host cell and pathogen responses to infection, and provide a solid framework to further understand the complex mechanisms involved in immunity to M. tuberculosis and in mycobacterial adaptation to different intracellular environments.

Item Type: Article
Additional Information: PubMed ID: 18167562
Keywords: Mycobacterium Tuberculosis Infection Transcriptional profiling Host-pathogen interactions
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: Q Science > QR Microbiology > QR0075 Bacteria
Q Science > QR Microbiology > QR0180 Immunology
R Medicine > R Medicine (General)
Depositing User: Simon Waddell
Date Deposited: 22 Aug 2011 13:39
Last Modified: 07 Mar 2017 06:44
URI: http://sro.sussex.ac.uk/id/eprint/7063
Google Scholar:47 Citations

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