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Generation of multi-innervated dendritic spines as a novel mechanism of long-term memory formation

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posted on 2023-06-09, 08:24 authored by Karl Peter Giese, Wajeeha AzizWajeeha Aziz, Igor Kraev, Michael G Stewart
NMDA receptor-dependent long-term potentiation (LTP) at hippocampal CA1 synapses is a well-accepted mechanism underlying long-term memory (LTM) formation. However, studies with mice that lack threonine-286 autophosphorylation of aCaMKII have shown that hippocampal LTM can be formed despite absence of NMDA receptor-dependent CA1 LTP. After multiple training trials, LTM formation in these mutants is linked to the generation of multi-innervated dendritic spines (MIS), a spine that receives typically two presynaptic inputs. PSD-95 overexpression is sufficient for MIS generation and depends on mTOR signaling. LTM that involves MIS generation appears less modifiable upon retrieval in comparison to LTM without MIS generation. Taken together, MIS generation appears to be a novel LTM mechanism after multiple training trials, which may occur in diseases with impaired LTP or conditions affecting negative feedback CaMKII signaling at the synapse.

History

Publication status

  • Published

File Version

  • Published version

Journal

Neurobiology of learning and memory

ISSN

1095-9564

Publisher

Elsevier

Volume

124

Page range

48-51

Department affiliated with

  • BSMS Neuroscience Publications

Research groups affiliated with

  • Sussex Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-10-23

First Open Access (FOA) Date

2017-10-23

First Compliant Deposit (FCD) Date

2017-10-23

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