Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum

Waddell, Simon, Garton, Natalie J, Sherratt, Anna L, Lee, Su-Min, Smith, Rebecca J, Senner, Claire, Hinds, Jason, Rajakumar, Kumar, Adegbola, Richard A, Besra, Gurdyal S, Butcher, Philip D and Barer, Michael R (2008) Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum. PLoS Medicine, 5 (4). pp. 634-645. ISSN 1549-1676

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Abstract

As nonreplicating tubercle bacilli are tolerant to the cidal action of antibiotics and resistant to multiple stresses, identification of this persister-like population of tubercle bacilli in sputum presents exciting and tractable new opportunities to investigate both responses to chemotherapy and the transmission of tuberculosis.

Item Type: Article
Additional Information: IDS Number: 293XX Article Number: e75
Keywords: Mycobacterium Infection Transcriptional profiling Tuberculosis Host-pathogen interactions
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Subjects: Q Science > QR Microbiology > QR0075 Bacteria
Q Science > QR Microbiology > QR0180 Immunology
R Medicine > RC Internal medicine
Depositing User: Simon Waddell
Date Deposited: 19 Aug 2011 15:02
Last Modified: 07 Mar 2017 06:46
URI: http://sro.sussex.ac.uk/id/eprint/7061
Google Scholar:90 Citations

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