The interaction between a HSP-70 gene variant with dietary calories in determining serum markers of inflammation and cardiovascular risk

Mehramiz, Mehrane, Hassanian, Seyed Mahdi, Mardan-Nik, Maryam, Pasdar, Alireza, Jamialahmadi, Khadijeh, Fiuji, Hamid, Moetamani-Ahmadi, Mehrdad, Parizadeh, Seyed Mohammad Reza, Moohebati, Mohsen, Heidari-Bakavoli, Alireza, Ebrahimi, Mahmoud, Ferns, Gordon, Ghayour-Mobarhan, Majid and Avan, Amir (2017) The interaction between a HSP-70 gene variant with dietary calories in determining serum markers of inflammation and cardiovascular risk. Clinical Nutrition. ISSN 0261-5614

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Abstract

Background: The high prevalence of cardiovascular disease (CVD) globally is attributable to an interaction between environmental and genetic factors. Gene × diet interaction studies aim to explore how a modifiable factor interacts with genetic predispositions. Here we have explored the interaction of a heat shock protein (HSP70) gene polymorphism (+1267A>G) with dietary intake and their possible association with serum C-reactive protein (CRP), an inflammatory marker, that is a major component of CVD risk.
Methods: HSP70 genotype was determined using a TaqMan real time PCR based method. Genetic variation of the HSP70 gene +1267A>G locus. Dietary intake was assessed using a dietary questionnaire. Serum high sensitivity (Hs) CRP and other cardiovascular risk factors were assessed by routine methods. This included coronary angioplasty to determine the presence of coronary artery stenosis.
Results: There were significant differences between serum lipid profile and Hs-CRP across the genotypes for Hsp70. The carriers of G allele had higher serum hs-CRP concentrations, compared with the AA homozygotes, with the wild genotype. Interaction analysis showed the association was modulated by total energy intake; the interaction of high energy intake with GG genotype: RERI= 0.77, AP= 0.26, S=1.6.
Conclusion: We have found a significant association between the +1267A>G variant of the HSP70 gene with cardiovascular risk factors and serum hs-CRP concentrations. It is possible that a low energy diet could ameliorate the unfavorable effects of G allele of HSP70.

Item Type: Article
Keywords: Chronic disease, Cardiovascular disease, Inflammation, HSP70, Gene/diet interaction
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Gordon Ferns
Date Deposited: 13 Oct 2017 08:34
Last Modified: 10 Nov 2017 11:31
URI: http://sro.sussex.ac.uk/id/eprint/70508

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