Uncoupling of neurogenesis and differentiation during retinal development

Engerer, Peter, Suzuki, Sachihiro, Yoshimatsu, Takeshi, Chapouton, Prisca, Obeng, Nancy, Odermatt, Benjamin, Williams, Philip, Misgeld, Thomas and Godinho, Leanne (2017) Uncoupling of neurogenesis and differentiation during retinal development. The EMBO Journal, 36 (9). pp. 1134-1146. ISSN 0261-4189

[img] PDF - Published Version
Available under License Creative Commons Attribution No Derivatives.

Download (1MB)

Abstract

Conventionally, neuronal development is regarded to follow a stereotypic sequence of neurogenesis, migration, and differentiation. We demonstrate that this notion is not a general principle of neuronal development by documenting the timing of mitosis in relation to multiple differentiation events for bipolar cells (BCs) in the zebrafish retina using in vivo imaging. We found that BC progenitors undergo terminal neurogenic divisions while in markedly disparate stages of neuronal differentiation. Remarkably, the differentiation state of individual BC progenitors at mitosis is not arbitrary but matches the differentiation state of post-mitotic BCs in their surround. By experimentally shifting the relative timing of progenitor division and differentiation, we provide evidence that neurogenesis and differentiation can occur independently of each other. We propose that the uncoupling of neurogenesis and differentiation could provide neurogenic programs with flexibility, while allowing for synchronous neuronal development within a continuously expanding cell pool.

Item Type: Article
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
Subjects: Q Science
Depositing User: Takeshi Yoshimatsu
Date Deposited: 11 Oct 2017 08:30
Last Modified: 11 Oct 2017 08:31
URI: http://sro.sussex.ac.uk/id/eprint/70480

View download statistics for this item

📧 Request an update