AC- Farina et al (2017) - Experimental Gerontology.pdf (1017.51 kB)
Homocysteine concentrations in the cognitive progression of Alzheimer’s disease
journal contribution
posted on 2023-06-09, 08:12 authored by Nicolas Farina, Fredrik Jernerén, Cheryl Turner, Kathryn Hart, Naji TabetNaji TabetObjectives: Hyperhomocysteinemia in Alzheimer’s disease (AD) is widely reported and appears to worsen as the disease progresses. While active dietary intervention with vitamins B12 and folate decreases homocysteine blood levels, with promising clinical outcomes in Mild Cognitive Impairment (MCI), this so far has not been replicated in established AD populations. The aim of the study is to explore the relationship between hyperhomocystenemia and relevant vitamins as the disease progresses. Methods: In this longitudinal cohort study, 38 participants with mild to moderate AD were followed for an average period of 13 months. Plasma folate, vitamin B12 and homocysteine concentrations were measured at baseline and at follow-up. Dietary intake of B vitamins was also measured. Spearman’s correlations were conducted by homocysteine and B vitamin status. Results: As expected, cognitive status significantly declined over the follow-up period and this was paralleled by a significant increase in homocysteine concentrations (p=0.006). However, during this follow-up period there was no significant decline in neither dietary intake, nor the corresponding blood concentrations of vitamin B12/folate, with both remaining within normal values. Changes in blood concentrations of B vitamins were not associated with changes in homocysteine levels (p>0.05). Conclusion: In this study, the increase in homocysteine observed in AD patients as the disease progresses cannot be solely explained by dietary and blood levels of folate and vitamin B12. Other dietary and non-dietary factors may contribute to hyperhomocysteinemia and its toxic effect in AD, which needs to be explored to optimise timely intervention strategies.
History
Publication status
- Published
File Version
- Accepted version
Journal
Experimental GerontologyISSN
0531-5565Publisher
ElsevierExternal DOI
Volume
99Page range
146-150Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-10-09First Open Access (FOA) Date
2018-10-10First Compliant Deposit (FCD) Date
2017-10-09Usage metrics
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