Ganeshan, Balaji, Burnand, Katherine, Young, Rupert, Chatwin, Chris and Miles, Kenneth A. (2011) Dynamic contrast-enhanced texture analysis of the liver: initial assessment in colorectal cancer. Investigative Radiology, 46 (3). pp. 160-168. ISSN 0020-9996Full text not available from this repository.
Purpose: To undertake an initial assessment of the potential utility of dynamic contrast-enhanced texture analysis (DCE-TA) of the liver in patients with colorectal cancer. Materials and Methods: TA comprised measurement of mean gray-level intensity, entropy, and uniformity with and without selective-scale filtration using a band-pass filter to highlight different spatial frequencies reflecting fine, medium, and coarse textures. An initial phantom study assessed the sensitivity of each texture qualifier to computed tomography (CT) acquisition parameters. Texture was analyzed in DCE-CT series from 27 colorectal cancer patients having apparently normal hepatic morphology (node-negative: n = 8, node-positive: n = 19). Averaged changes in hepatic texture induced by contrast material were assessed qualitatively and quantitatively by using kinetic modeling to calculate hepatic perfusion indices following fine, medium, and coarse image filtration. Results: All texture qualifiers were less sensitive to changes in CT acquisition parameters than measurement of CT attenuation. Temporal changes in hepatic texture were qualitatively different from changes in enhancement. Statistically significant differences between node-negative and node-positive patients were observed for at least 1 time period for measurements of hepatic enhancement and for all texture parameters. The differences were most statistically significant and occurred over the greatest number of time periods for fine texture quantified as mean gray-level intensity (5 time periods, minimum P value: 0.006) followed by fine texture quantified as entropy (4 time points, minimum P value: 0.006). There was no difference in hepatic perfusion indices for the 2 groups. CONCLUSIONS:: DCE-TA is a potentially useful adjunct to DCE-CT warranting further investigation.
|Additional Information:||PubMed ID: 21102348 CODEN: INVRA|
|Schools and Departments:||Brighton and Sussex Medical School > Clinical and Laboratory Investigation|
|Subjects:||R Medicine > R Medicine (General) > R855 Medical technology
R Medicine > R Medicine (General) > R856 Biomedical engineering. Electronics. Instrumentation
R Medicine > R Medicine (General) > R858 Computer applications to medicine. Medical informatics
R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
|Depositing User:||Balaji Ganeshan|
|Date Deposited:||18 Aug 2011 14:56|
|Last Modified:||30 Nov 2012 16:55|
|Google Scholar:||3 Citations|