Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety

Sansook, Supojjanee, Ocasio, Cory A, Day, Iain J, Tizzard, Graham J, Coles, Simon, Fedorov, Oleg, Bennett, James, Elkins, Jon and Spencer, John (2017) Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Organic and Biomolecular Chemistry, 40 (15). pp. 8655-8660. ISSN 1477-0520

[img] PDF - Accepted Version
Restricted to SRO admin only

Download (855kB)
[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

A series of 3-methylidene-1H-indol-2(3H)-ones substituted with a 5- or 6- pentafluorosulfanyl group has been synthesized by a Knoevenagel condensation reaction of SF5-substituted oxindoles with a range of aldehydes. The resulting products were characterized by x-ray crystallography studies and were tested for biological activity versus a panel of cell lines and protein kinases. Some exhibited single digit nM activity.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry
Q Science > QD Chemistry > QD0241 Organic chemistry > QD0411 Organometallic chemistry and compounds
Q Science > QD Chemistry > QD0901 Crystallography
Depositing User: John Spencer
Date Deposited: 06 Oct 2017 08:16
Last Modified: 22 Nov 2017 12:09
URI: http://sro.sussex.ac.uk/id/eprint/70385

View download statistics for this item

📧 Request an update