Asymmetry of parietal interhemispheric connections in humans

Koch, Giacomo, Cercignani, Mara, Bonnì, Sonia, Giacobbe, Viola, Bucchi, Giulia, Versace, Viviana, Caltagirone, Carlo and Bozzali, Marco (2011) Asymmetry of parietal interhemispheric connections in humans. Journal of Neuroscience, 31 (24). pp. 8967-8975. ISSN 1529-2401

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Abstract

Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate is still largely unknown. Here, using a method of trifocal transcranial magnetic stimulation, we show that the right, but not left, human posterior parietal cortex exerts a strong inhibitory activity over the contralateral homologous area by a short-latency connection. We also clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Laboratory Investigation
Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Mara Cercignani
Date Deposited: 17 Aug 2011 13:26
Last Modified: 09 Sep 2017 04:35
URI: http://sro.sussex.ac.uk/id/eprint/7033
Google Scholar:3 Citations

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