The interaction between lentiviral integrase and LEDGF: structural and functional insights

Hare, Stephen and Cherepanov, Peter (2009) The interaction between lentiviral integrase and LEDGF: structural and functional insights. Viruses, 1 (3). pp. 780-801. ISSN 1999-4915

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (464kB)

Abstract

Since its initial description as an HIV-1 integrase (IN) interactor seven years ago, LEDGF has become one of the best-characterized host factors involved in viral replication. Results of intensive studies in several laboratories indicated that the protein serves as a targeting factor for the lentiviral DNA integration machinery, and accounts for the characteristic preference of Lentivirus to integrate within active transcription units. The IN-LEDGF interaction has been put forward as a promising target for antiretroviral drug development and as a potential tool to improve safety of lentiviral vectors for use in gene therapy. Additionally, as a natural ligand of lentiviral IN proteins, LEDGF has been successfully used in structural biology studies of retroviral DNA integration. This review focuses on the structural aspects of the IN-LEDGF interaction and their functional consequences.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Stephen Hare
Date Deposited: 21 Sep 2017 14:32
Last Modified: 21 Sep 2017 14:32
URI: http://sro.sussex.ac.uk/id/eprint/70288

View download statistics for this item

📧 Request an update