1-s2.0-S1570963917300146-main.pdf (2.96 MB)
Diverse structural approaches to haem appropriation by pathogenic bacteria
journal contribution
posted on 2023-06-09, 08:00 authored by Stephen HareThe critical need for iron presents a challenge for pathogenic bacteria that must survive in an environment bereft of accessible iron due to a natural low bioavailability and their host's nutritional immunity. Appropriating haem, either direct from host haemoproteins or by secreting haem-scavenging haemophores, is one way pathogenic bacteria can overcome this challenge. After capturing their target, haem appropriation systems must remove haem from a high-affinity binding site (on the host haemoprotein or bacterial haemophore) and transfer it to a binding site of lower affinity on a bacterial receptor. Structural information is now available to show how, using a combination of induced structural changes and steric clashes, bacteria are able to extract haem from haemophores, haemopexin and haemoglobin. This review focuses on structural descriptions of these bacterial haem acquisition systems, summarising how they bind haem and their target haemoproteins with particularly emphasis on the mechanism of haem extraction.
History
Publication status
- Published
File Version
- Published version
Journal
BBA - Biochimica et Biophysica ActaISSN
0006-3002Publisher
ElsevierExternal DOI
Issue
4Volume
1865Page range
422-433Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2017-09-21First Open Access (FOA) Date
2017-09-21First Compliant Deposit (FCD) Date
2017-09-21Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC