Diverse structural approaches to haem appropriation by pathogenic bacteria

Hare, Stephen A (2017) Diverse structural approaches to haem appropriation by pathogenic bacteria. BBA - Biochimica et Biophysica Acta, 1865 (4). pp. 422-433. ISSN 0006-3002

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Abstract

The critical need for iron presents a challenge for pathogenic bacteria that must survive in an environment bereft of accessible iron due to a natural low bioavailability and their host's nutritional immunity. Appropriating haem, either direct from host haemoproteins or by secreting haem-scavenging haemophores, is one way pathogenic bacteria can overcome this challenge. After capturing their target, haem appropriation systems must remove haem from a high-affinity binding site (on the host haemoprotein or bacterial haemophore) and transfer it to a binding site of lower affinity on a bacterial receptor. Structural information is now available to show how, using a combination of induced structural changes and steric clashes, bacteria are able to extract haem from haemophores, haemopexin and haemoglobin. This review focuses on structural descriptions of these bacterial haem acquisition systems, summarising how they bind haem and their target haemoproteins with particularly emphasis on the mechanism of haem extraction.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Stephen Hare
Date Deposited: 21 Sep 2017 15:21
Last Modified: 05 Oct 2017 13:15
URI: http://sro.sussex.ac.uk/id/eprint/70270

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