Brydon, Lena, Harrison, Neil A., Walker, Cicely, Steptoe, Andrew and Critchley, Hugo D. (2008) Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans. Biological Psychiatry, 63 (11). pp. 1022-1029. ISSN 1873-2402
- Published Version
BACKGROUND: Systemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain.
METHODS: We used functional magnetic resonance brain imaging (fMRI) to investigate neural effects of peripheral inflammation following typhoid vaccination in 16 healthy men, using a double-blind, randomized, crossover-controlled design.
RESULTS: Vaccination had no global effect on neurovascular coupling but markedly perturbed neural reactivity within substantia nigra during low-level visual stimulation. During a cognitive task, individuals in whom typhoid vaccination engendered higher levels of circulating interleukin-6 had significantly slower reaction time responses. Prolonged reaction times and larger interleukin-6 responses were associated with evoked neural activity within substantia nigra.
CONCLUSIONS: Our findings provide mechanistic insights into the interaction between inflammation
|Additional Information:||This paper is supported by a Wellcome Trust Grant for Prof Hugo Critchley. He has given his permission to put the full published version online as this paper is Open Access as is the policy of Wellcome. If you have any queries regarding this please email him in the first instance H.Critchley@bsms.ac.uk|
|Keywords:||Cytokines, fMRI, peripheral inflammation, psychomotor slowing, substantia nigra|
|Schools and Departments:||Brighton and Sussex Medical School > Clinical Medicine|
|Subjects:||R Medicine > R Medicine (General)
R Medicine > R Medicine (General) > R722 Missionary medicine. Medical missionaries
R Medicine > R Medicine (General) > R726.5 Medicine and disease in relation to psychology. Terminal care.
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
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R Medicine > RM Therapeutics. Pharmacology
|Depositing User:||Hazelle Woodhurst|
|Date Deposited:||19 Aug 2011 15:12|
|Last Modified:||07 Mar 2017 09:10|
|Google Scholar:||40 Citations|