Serum high sensitive C reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study

Bagherniya, Mohammad, Khayyatzadeh, Sayyed Saeid, Bakavoli, Ali Reza Heidari, Ferns, Gordon A, Ebrahimi, Mahmoud, Safarian, Mohammad, Nematy, Mohsen and Ghayour-Mobarhan, Majid (2017) Serum high sensitive C reactive protein is associated with dietary intakes in diabetic patients with and without hypertension: a cross-sectional study. Annals of Clinical Biochemistry. ISSN 0004-5632

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Abstract

Background: Serum C reactive protein (CRP) concentrations independently predict the development of diabetes, metabolic syndrome and cardiovascular disease. However, the impact of dietary factors on serum CRP concentrations in diabetic patients has received limited attention. We aimed to investigate the association between dietary factors and serum CRP, measured using a high sensitivity (hs-)assay, among diabetic patients with and without hypertension and healthy subjects.
Methods: In this cross-sectional study, diabetics with (n=325) and without hypertension (n=599) and healthy individuals (n=1220) were recruited in Mashhad, Iran. Dietary intake was assessed by 24-hour recall. Biochemical parameters including serum hs-CRP were measured using standard protocols. Stepwise multiple regression analysis was used to predict whether serum hs-CRP concentration was associated with dietary constituents.
Results: hs-CRP was significantly higher among hypertensive and non-hypertensive diabetic patients compared to healthy subjects (p<0.001). The dietary intake of zinc +6.4% and calcium -3.4%, and BMI +3.9% explained approximately 13.7% of the variation in serum hs-CRP among diabetic hypertensive patients. Approximately, 9.7% of the variation in serum hs-CRP in diabetic non-hypertensive patients could be explained by BMI, and intake of sodium, iron and cholesterol. In the healthy subjects approximately 4.4% of the total variation in serum hs-CRP concentration could be explained by cholesterol consumption and waist circumference.
Conclusion: Serum hs-CRP concentrations were found to be a significant predictor for hypertensive and non-hypertensive diabetic subjects. There was a significant association between dietary factors include zinc, iron, sodium and cholesterol and serum hs-CRP whilst there was an inverse association between dietary calcium and serum hs-CRP in diabetic hypertensive individuals.

Item Type: Article
Keywords: hs-CRP; inflammation; diabetes; hypertension; dietary intake.
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Gordon Ferns
Date Deposited: 18 Sep 2017 09:25
Last Modified: 26 Sep 2017 09:35
URI: http://sro.sussex.ac.uk/id/eprint/70219

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