Chromatin reorganisation in Epstein-Barr virus-infected cells and its role in cancer development

West, Michelle (2017) Chromatin reorganisation in Epstein-Barr virus-infected cells and its role in cancer development. Current Opinion in Virology, 26. pp. 149-155. ISSN 1879-6257

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Abstract

The oncogenic Epstein-Barr virus (EBV) growth transforms B cells and drives lymphoma and carcinoma development. The virus encodes four key transcription factors (EBNA2, EBNA3A, EBNA3B and EBNA3C) that hijack host cell factors to bind gene control elements and reprogramme infected B cells. These viral factors predominantly target long-range enhancers to alter the expression of host cell genes that control B cell growth and survival and facilitate virus persistence. Enhancer and superenhancer binding by these EBNAs results in large-scale reorganisation of three-dimensional enhancer–promoter architecture to drive the overexpression of oncogenes, the silencing of tumour suppressors and the modulation of transcription, cell-cycle progression, migration and adhesion.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Research Centres and Groups: Gene Expression Research Group
Subjects: Q Science > QH Natural history > QH0301 Biology > QH0426 Genetics > QH0447 Genes. Alleles. Genome
Q Science > QH Natural history > QH0301 Biology > QH0573 Cytology > QH0600 Chromosomes
Q Science > QR Microbiology > QR0355 Virology
Depositing User: Michelle West
Date Deposited: 12 Sep 2017 14:59
Last Modified: 12 Sep 2017 15:04
URI: http://sro.sussex.ac.uk/id/eprint/70091

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