Anti-inflammatory effects of eugenol nanoemulsion as a topical delivery system

Esmaeili, Fariba, Rajabnezhad, Saeid, Partoazar, Ali Reza, Mehr, Shahram Ejtemaei, Faridi-Majidi, Reza, Sahebgharani, Mousa, Syedmoradi, Leila, Rajabnejad, Mohammad Reza and Amani, Amir (2015) Anti-inflammatory effects of eugenol nanoemulsion as a topical delivery system. Pharmaceutical Development and Technology, 21 (7). pp. 887-893. ISSN 1083-7450

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Abstract

Eugenol is the main constituent of clove oil with anti-inflammatory properties. In this work, for the first time, O/W nanoemulsion of eugenol was designed for the evaluation of anti-inflammatory effects as a topical delivery system. Topical formulations containing 1%, 2% and 4% of eugenol as well as a nanoemulsion system containing 4% eugenol and 0.5% piroxicam were prepared. Further to physicochemical examinations, such as determination of particle size, polydispersity index, zeta potential and physical stability, anti-inflammatory activity was examined in carrageenan-induced paw edema in rats. The optimum formulation was found to contain 2% eugenol (oil phase), 14% Tween 20 (surfactant) and 14% isopropyl alcohol (co-surfactant) in water. Nanoemulsion with polydispersity index of 0.3 and median droplet diameter of 24.4 nm (d50) was obtained. Animal studies revealed that the nanoemulsions exhibited significantly improved anti-inflammatory activity after 1.5 h, compared with marketed piroxicam gel. Additionally, it was shown that increasing the concentration of eugenol did not show higher inhibition of inflammation. Also, the nanoemulsion having piroxicam showed less anti-inflammatory properties compared with the nanoemulsion without piroxicam.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
School of Life Sciences > Chemistry
Research Centres and Groups: Pharma Supply Chains and Healthcare Technology
Subjects: R Medicine > RS Pharmacy and materia medica > RS0125 Formularies. Collected prescriptions
R Medicine > RS Pharmacy and materia medica > RS0139 Pharmacopoeias
R Medicine > RS Pharmacy and materia medica > RS0151 Dispensatories
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Depositing User: Saeid Rajabnezhad
Date Deposited: 12 Sep 2017 08:14
Last Modified: 12 Sep 2017 08:19
URI: http://sro.sussex.ac.uk/id/eprint/70083
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