Inotropes for preterm babies during the transition period after birth: friend or foe?

Rabe, Heike and Rojas-Anaya, Hector (2017) Inotropes for preterm babies during the transition period after birth: friend or foe? ADC Fetal and Neonatal Edition, 102 (6). pp. 547-550. ISSN 1359-2998

[img] PDF (This article has been accepted for publication in ADC Fetal and Neonatal Edition following peer review. The definitive copyedited, typeset version is available online at: http://fn.bmj.com/content/early/2017/08/17/archdischild-2016-311709) - Accepted Version
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Abstract

During the transition to extrauterine life, preterm infants are at high risk of developing circulatory failure. Currently, hypotension is used as major diagnostic criteria for starting treatments such as fluid boluses, inotropes or steroids. Most of these treatment options have not been studied in large randomised controlled trials for efficacy and safety and are under discussions. A wide variety in their use is reported in the literature and clear evidence about which inotrope or other treatment should be preferred is lacking. In addition, there is ongoing debate about the appropriate threshold values for blood pressure. Other diagnostic measures for poor circulation are functional echocardiography, near-infrared spectroscopy, capillary refill time, base excess and serum lactate. Large randomised controlled trials for the use of dopamine and dobutamine in preterm infants <32 weeks gestation are under way to fill the knowledge gaps on the assessment of circulatory compromise and on efficacy and safety of the studied age-appropriate drug formulations.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Depositing User: Katie Isaac
Date Deposited: 11 Sep 2017 08:15
Last Modified: 30 Oct 2017 12:26
URI: http://sro.sussex.ac.uk/id/eprint/70071

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