N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts

Khan, Raysa, Felix, Robert, Kemmitt, Paul D, Coles, Simon J, Tizzard, Graham J and Spencer, John (2017) N1-arylation of 1,4-benzodiazepine-2-ones with diaryliodonium salts. Synlett. ISSN 0936-5214

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Abstract

A library of N1-arylated 5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones has been synthesized starting with unsymmetrical diaryliodonium salts using aqueous ammonia as a base. This can also be applied to a similar 1,3,4-benzotriazepin-2-one derivative.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry
Depositing User: John Spencer
Date Deposited: 07 Sep 2017 09:15
Last Modified: 19 Oct 2017 09:50
URI: http://sro.sussex.ac.uk/id/eprint/70020

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A Precompetitive Modular Peptidomimetic Toolkit for Targeting PPIs iCASEG1436EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCILEP/M507568/1