National disability-adjusted life years(DALYs) for 257 diseases and injuries in Ethiopia, 1990–2015: findings from the global burden of disease study 2015

Misganaw, Awoke, Adama Melaku, Yohannes, Assefa Tessema, Gizachew, Deribew, Amare, Deribe, Kebede, Ferede Abera, Sernaw, Dessalegn, Muluken, Lakew, Yihunie, Bekele, Tolesa, Haregu, Tilahun N, Amare, Azmeraw T, Gedefaw, Molla, Mohammed, Mesoud, Desalegn Yisraw, Biruck, Abrha Damtew, Solomon, Achoki, Tom, Blore, Jed, Krohn, Kristopher J, Assefa, Yibeltal, Kifle, Mahlet and Naghavi, Mohsen (2017) National disability-adjusted life years(DALYs) for 257 diseases and injuries in Ethiopia, 1990–2015: findings from the global burden of disease study 2015. Population Health Metrics. ISSN 0014-1755 (Accepted)

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Abstract

Background: Disability-adjusted life years (DALYs) provide a summary measure of health and can be a critical input
to guide health systems, investments, and priority-setting in Ethiopia. We aimed to determine the leading causes of
premature mortality and disability using DALYs and describe the relative burden of disease and injuries in Ethiopia.

Methods: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for non-fatal disease burden, cause-specific mortality, and all-cause mortality to derive age-standardized DALYs by sex
for Ethiopia for each year. We calculated DALYs by summing years of life lost due to premature mortality (YLLs) and
years lived with disability (YLDs) for each age group and sex. Causes of death by age, sex, and year were measured
mainly using Causes of Death Ensemble modeling. To estimate YLDs, a Bayesian meta-regression method was used.
We reported DALY rates per 100,000 for communicable, maternal, neonatal, and nutritional (CMNN) disorders,
non-communicable diseases, and injuries, with 95% uncertainty intervals (UI) for Ethiopia.

Results: Non-communicable diseases caused 23,118.1 (95% UI, 17,124.4–30,579.6), CMNN disorders resulted in
20,200.7 (95% UI, 16,532.2–24,917.9), and injuries caused 3781 (95% UI, 2642.9–5500.6) age-standardized DALYs
per 100,000 in Ethiopia in 2015. Lower respiratory infections, diarrheal diseases, and tuberculosis were the top three leading causes of DALYs in 2015, accounting for 2998 (95% UI, 2173.7–4029), 2592.5 (95% UI, 1850.7–3495.1), and 2562.9 (95% UI, 1466.1–4220.7) DALYs per 100,000, respectively. Ischemic heart disease and cerebrovascular disease were the fourth and fifth leading causes of age-standardized DALYs, with rates of 2535.7 (95% UI, 1603.7–3843.2) and 2159.9 (95% UI, 1369.7–3216.3) per 100,000, respectively. The following causes showed a reduction of 60% or more over the last 25 years: lower respiratory infections, diarrheal diseases, tuberculosis, neonatal encephalopathy, preterm birth complications, meningitis, malaria, protein-energy malnutrition, iron-deficiency anemia, measles, war and legal intervention, and maternal hemorrhage.

Item Type: Article
Keywords: Disability-adjusted life years, Communicable disease, Maternal and neonatal disease, Nutritional deficiency disorders, Non-communicable diseases, Injuries, Ethiopia
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Research Centres and Groups: Wellcome Trust Brighton and Sussex Centre for Global Health Research
Depositing User: Esther Garibay
Date Deposited: 06 Sep 2017 13:50
Last Modified: 06 Sep 2017 13:52
URI: http://sro.sussex.ac.uk/id/eprint/70015

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