Under pressure: Response urgency modulates striatal and insula activity during decision-making under risk

Jones, Catherine L, Minati, Ludovico, Harrison, Neil A., Ward, Jamie and Critchley, Hugo D. (2011) Under pressure: Response urgency modulates striatal and insula activity during decision-making under risk. PLoS ONE, 6 (6). ISSN 1932-6203

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Abstract

When deciding whether to bet in situations that involve potential monetary loss or gain (mixed gambles), a subjective sense of pressure can influence the evaluation of the expected utility associated with each choice option. Here, we explored how gambling decisions, their psychophysiological and neural counterparts are modulated by an induced sense of urgency to respond. Urgency influenced decision times and evoked heart rate responses, interacting with the expected value of each gamble. Using functional MRI, we observed that this interaction was associated with changes in the activity of the striatum, a critical region for both reward and choice selection, and within the insula, a region implicated as the substrate of affective feelings arising from interoceptive signals which influence motivational behavior. Our findings bridge current psychophysiological and neurobiological models of value representation and action-programming, identifying the striatum and insular cortex as the key substrates of decision-making under risk and urgency.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry
?? RC0435 ??
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Depositing User: Hazelle Woodhurst
Date Deposited: 26 Aug 2011 15:41
Last Modified: 07 Mar 2017 06:02
URI: http://sro.sussex.ac.uk/id/eprint/6985
Google Scholar:4 Citations

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